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Sermorelin

Sermorelin

Growth-hormone axis (GHRH analogue)

GRF(1-29), formerly Geref
Off Cat. 2 – PCAC review pending Moderate-caution
Status & caution. Had an earlier FDA approval (Geref, withdrawn for commercial — not safety — reasons) and is still prepared by some licensed compounding pharmacies by prescription, a more established footing than most peptides here. Not currently an FDA-approved finished product; verify current compounding status. Short half-life; stimulates the GH axis. Long-term outcome data are limited.

At a glance

Molecular formula
C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular weight
≈3,357.9 g/mol
Sequence / structure
First 29 residues of human GHRH (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu…).
Regulatory status
Off Cat. 2 – PCAC review pending

Indications & what it's studied for

Historically a diagnostic/therapeutic GH agent; now used in anti-aging/wellness clinics to raise GH/IGF-1 for body composition, recovery, and sleep.

Contraindications & cautions

Active cancer; pituitary disease; pregnancy; hypersensitivity. Caution with hypothyroidism (treat first) and glucose intolerance.

Commonly reported dosing

Reported, not recommended. The following describes what appears in research literature and community use. It is not a protocol, and unapproved peptides have no validated human dosing.

Commonly reported as a small nightly subcutaneous dose to mimic the natural GH pulse; reconstituted and refrigerated.

Routes of administration

Subcutaneous injection, usually at night.

Don't combine with

Somatostatin, glucocorticoids, and antithyroid agents blunt the response.

Reported to stack with

Frequently combined with a GHRP/secretagogue (ipamorelin) for a synergistic GH pulse — a popular but not safety-validated pairing.
Note: "stacking" combines multiple agents and multiplies unknowns; popularity of a combination is not evidence of its safety.

What the research actually shows

Older clinical work on GH secretion and growth; modern wellness use rests largely on mechanism and anecdote rather than long-term trials.

Before acting on anything here, see Safety & the grey market and how to read a COA.

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